Journal article
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation.
- Abstract:
-
Cells rely on the precise action of proteins that detect and repair DNA damage. However, gene expression noise causes fluctuations in protein abundances that may compromise repair. For the Ada protein in Escherichia coli, which induces its own expression upon repairing DNA alkylation damage, we found that undamaged cells on average produce one Ada molecule per generation. Because production is stochastic, many cells have no Ada molecules and cannot induce the damage response until the first e...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Uphoff, S
Sherratt, D
Grant:
Junior Research Fellowship
Investigator Award (099204/Z/12Z
Strategic Award (091911
+ St John’s
College, Oxford
More from this funder
Funding agency for:
Uphoff, S
Grant:
Junior Research Fellowship
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science (New York, N.Y.) Journal website
- Volume:
- 351
- Issue:
- 6277
- Pages:
- 1094-1097
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-02-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
Item Description
- Language:
- English
- Pubs id:
-
pubs:609011
- UUID:
-
uuid:ca371013-54f1-4459-aedb-604be2cb2d79
- Local pid:
- pubs:609011
- Source identifiers:
-
609011
- Deposit date:
- 2016-03-31
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, American Association for the Advancement of Science.
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