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Genetic mapping of variation in spatial learning in the mouse

Abstract:

Inbred strains of mice are known to differ in their performance in the Morris water maze task, a test of spatial discrimination and place navigation in rodents, but the genetic basis of individual variation in spatial learning is unknown. We have mapped genetic effects that contribute to the difference between two strains, DBA/2 and C57BL6/J, using an F2 intercross and methods to detect quantitative trait loci (QTL). We found two QTL, one on chromosome 4 and one on chromosome 12, that influen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
"University of Oxford", "Bioscientia, Center for Human Genetics, 55218 Ingelheim, Germany"
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Role:
Author
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Institution:
"Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Essex, UK"
Role:
Author
More by this author
Institution:
"Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Essex, UK"
Role:
Author
More by this author
Institution:
"Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Essex, UK"
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
23
Issue:
6
Pages:
2426-2433
Publication date:
2003-03-01
ISSN:
0270-6474
Language:
English
Keywords:
Subjects:
UUID:
uuid:ca32de17-3504-4e3a-b049-dec1ec9b99d7
Local pid:
ora:1036
Deposit date:
2008-03-14

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