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Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation.

Abstract:

We have established by differential display polymerase chain reaction of mRNA that interleukin (IL)-18 is expressed by osteoblastic stromal cells. The stromal cell populations used for comparison differed in their ability to promote osteoclast-like multinucleated cell (OCL) formation. mRNA for IL-18 was found to be expressed in greater abundance in lines that were unable to support OCL formation than in supportive cells. Recombinant IL-18 was found to inhibit OCL formation in cocultures of os...

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Publisher copy:
10.1084/jem.185.6.1005

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Journal:
Journal of experimental medicine More from this journal
Volume:
185
Issue:
6
Pages:
1005-1012
Publication date:
1997-03-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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