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Journal article

Structure and substrate specificity of the Pim-1 kinase.

Abstract:

The Pim kinases are a family of three vertebrate protein serine/threonine kinases (Pim-1, -2, and -3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group. Pim kinases are emerging as important mediators of cytokine signaling pathways in hematopoietic cells, and they contribute to the progression of certain leukemias and solid tumors. A number of cytoplasmic and nuclear proteins are phosphorylated by Pim kinases and may act as their effectors in normal physiology and in d...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m510711200

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Debreczeni, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
50
Pages:
41675-41682
Publication date:
2005-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ca29f5db-94f5-42d5-8823-e1d041690c6f
Source identifiers:
33267
Local pid:
pubs:33267

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