UDP-glucose dehydrogenase: structure and function of a potential drug target.

Journal article

Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in the present paper, and structure-based sequence comparison is used for subclassification of UGDH family members. The eukaryotic group of enzymes (UGDH-II) utilize an extended C-terminal domain for the f...

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Authors: Egger, S; Chaikuad, A; Kavanagh, K; Oppermann, U; Nidetzky, B

• Publication status: Published
• Journal: Biochemical Society transactions
• Volume: 38
• Issue: 5
• Pages: 1378-1385
• Publication date: 2010-10-01
• DOI: 10.1042/bst0381378
• EISSN: 1470-8752
• ISSN: 0300-5127
• Language: English
• Keywords: Humans; Uridine Diphosphate Glucuronic Acid; Enzyme Inhibitors; Hyaluronic Acid; Animals; Neoplasms; Uridine Diphosphate Glucose Dehydrogenase