Journal article icon

Journal article

Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?

Abstract:

Mutations in the C-terminal region of nucleophosmin in acute myeloid leukemia (AML) result in aberrant cytoplasmic nucleophosmin (cNPM) in leukemic blast cells which is detectable by immunocytochemistry in bone marrow trephine (BMT) biopsy sections. We tested whether cNPM is detectable by immunocytochemistry in air-dried smears of AML with nucleophosmin1 (NPM1) mutations. An immunoalkaline phosphatase method was developed using the OCI-AML3 cell line, known to have mutated NPM1, and assessed ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Haematologica More from this journal
Volume:
95
Issue:
4
Pages:
670-673
Publication date:
2010-04-01
DOI:
EISSN:
1592-8721
ISSN:
0390-6078
Language:
English
Keywords:
Pubs id:
pubs:246549
UUID:
uuid:ca2407f4-45a8-4cfd-b8d4-d1451fba90b6
Local pid:
pubs:246549
Source identifiers:
246549
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP