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Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria.

Abstract:

BACKGROUND: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues potentially confound the interpretation of PFHRP2 measurements. METHODS: Studies designed to detect deletion of Pfhrp2 and its paralog Pfhrp3 were undertaken with samples from patients in seven...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-11-276

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Institution:
University of Oxford
Role:
Author
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malar J Journal website
Volume:
11
Issue:
1
Pages:
Article: 276
Publication date:
2012-01-01
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:ca240140-5b86-4e49-9522-fadf09254dae
Source identifiers:
349837
Local pid:
pubs:349837

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