- Abstract:
-
Movement disability in advanced Parkinson's disease (PD) can be treated by high frequency stimulation (HFS) of the subthalamic nucleus (STN) but some patients experience psychiatric side-effects including depression, which is strongly linked to decreases in 5-hydroxytryptamine (5-HT). The current study investigated the effect of bilateral STN HFS on extracellular 5-HT in brain regions of anesthetized and freely moving rats as measured with microdialysis. Parallel in vivo electrophysiological ...
Expand abstract - Publisher copy:
- 10.1016/j.expneurol.2011.08.027
-
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- Journal:
- Experimental Neurology
- Volume:
- 233
- Issue:
- 1
- Pages:
- 145-153
- Publication date:
- 2012-01-05
- DOI:
- EISSN:
-
1090-2430
- ISSN:
-
0014-4886
- URN:
-
uuid:ca236cd8-10ad-418f-95d2-66739e33e2dc
- Source identifiers:
-
313639
- Local pid:
- pubs:313639
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmission
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