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A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmission

Abstract:

Movement disability in advanced Parkinson's disease (PD) can be treated by high frequency stimulation (HFS) of the subthalamic nucleus (STN) but some patients experience psychiatric side-effects including depression, which is strongly linked to decreases in 5-hydroxytryptamine (5-HT). The current study investigated the effect of bilateral STN HFS on extracellular 5-HT in brain regions of anesthetized and freely moving rats as measured with microdialysis. Parallel in vivo electrophysiological ...

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Journal:
Experimental Neurology
Volume:
233
Issue:
1
Pages:
145-153
Publication date:
2012-01-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:ca236cd8-10ad-418f-95d2-66739e33e2dc
Source identifiers:
313639
Local pid:
pubs:313639

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