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Journal article

Modulation of osteogenic differentiation in human skeletal cells in Vitro by 5-azacytidine.

Abstract:

Cellular differentiation is controlled by a variety of factors including gene methylation, which represses particular genes as cell fate is determined. The incorporation of 5-azacytidine (5azaC) into DNA in vitro prevents methylation and thus can alter cellular differentiation pathways. Human bone marrow fibroblasts and MG63 cells treated with 5azaC were used as models of osteogenic progenitors and of a more mature osteoblast phenotype, respectively. The capacity for differentiation of these ...

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Publication status:
Published

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Publisher copy:
10.1006/cbir.1998.0240

Authors


Journal:
Cell biology international
Volume:
22
Issue:
3
Pages:
207-215
Publication date:
1998-01-01
DOI:
EISSN:
1095-8355
ISSN:
1065-6995
URN:
uuid:ca1d6812-0af9-4218-a17c-9a9c2751bb4e
Source identifiers:
108416
Local pid:
pubs:108416

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