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Journal article

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction.

Abstract:

BACKGROUND: The neuronal isoform of nitric oxide synthase (nNOS) has been implicated in the regulation of basal and beta-adrenergic inotropy in normal and chronically infarcted hearts. Furthermore, myocardial nNOS expression and activity increase in failing hearts, raising the possibility that nNOS may influence left ventricular (LV) remodeling progression and functional deterioration after myocardial infarction (MI). METHODS AND RESULTS: We compared LV remodeling at 1, 4, and 8 weeks after ...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Hulbert, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Journal:
Circulation
Volume:
112
Issue:
24
Pages:
3729-3737
Publication date:
2005-12-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:ca17717d-4e7b-43b7-9527-4e16dc826092
Source identifiers:
105038
Local pid:
pubs:105038

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