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Journal article

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction.

Abstract:

BACKGROUND: The neuronal isoform of nitric oxide synthase (nNOS) has been implicated in the regulation of basal and beta-adrenergic inotropy in normal and chronically infarcted hearts. Furthermore, myocardial nNOS expression and activity increase in failing hearts, raising the possibility that nNOS may influence left ventricular (LV) remodeling progression and functional deterioration after myocardial infarction (MI). METHODS AND RESULTS: We compared LV remodeling at 1, 4, and 8 weeks after ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation More from this journal
Volume:
112
Issue:
24
Pages:
3729-3737
Publication date:
2005-12-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322

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