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Thesis

Studies towards the synthesis of complex amino acids derived from microsclerodermins

Abstract:

This thesis describes the studies towards the synthesis of β-amino acids found in the microsclerodermins, a family of complex macrocyclic hexapeptides. These β-amino acids have four or five contiguous stereocentres and an aliphatic side-chain. The synthetic route utilised an aminohydroxylation reaction to install the most challenging moiety in the structure - the 1,2- amino alcohol. The work aimed to construct the core structure (five contiguous stereocentres) of the β-amino acids and inst...

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Institution:
University of Oxford
Research group:
Timothy Donohoe
Oxford college:
Exeter College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:ca121a22-aee7-4da5-bd0d-dc7ee6e53bea
Local pid:
ora:8318

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