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Intact B cell tolerance in the absence of the first component of the classical complement pathway.

Abstract:

A critical role for complement in the regulation of self tolerance has been proposed to explain the strong association between complement deficiency and autoimmunity. To elucidate the role of the classical pathway of complement in the maintenance of B cell tolerance, C1q-deficient (C1qa-/-) mice were bred with anti-hen egg lysozyme (HEL) immunoglobulin (Ig(HEL)) and soluble HEL (sHEL) transgenic mice. B cell tolerance was intact in C1qa-/- mice. In vivo, double-transgenic (Ig(HEL)/sHEL) C1qa-...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
European journal of immunology More from this journal
Volume:
31
Issue:
7
Pages:
2087-2093
Publication date:
2001-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:10721
UUID:
uuid:ca1083bd-6aae-4040-a773-824bb5431867
Local pid:
pubs:10721
Source identifiers:
10721
Deposit date:
2012-12-19

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