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Noncanonical functions of microRNA pathway enzymes – Drosha, DGCR8, Dicer and Ago proteins

Abstract:
MicroRNAs (miRNAs) are small regulatory noncoding RNAs that are generated in the canonical RNA interference (RNAi) pathway. Drosha, DiGeorge syndrome critical region 8 (DGCR8) and Dicer are key players in miRNA biogenesis. Argonaute (Ago) proteins bind to miRNAs and are guided by them to find messenger RNA targets and carry out post‐transcriptional silencing of protein‐coding genes. Recently, emerging evidence suggests that RNAi factors have a range of noncanonical functions that are beyond miRNA biogenesis. These functions pertain to various biological processes, such as development, transcriptional regulation, RNA processing and maintenance of genome integrity. Here, we review recent literature reporting miRNA‐independent, noncanonical functions of Drosha, DGCR8, Dicer and Ago proteins and discuss the importance of these functions.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/1873-3468.13196

Authors

More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-9940-1175
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Publisher:
Wiley
Journal:
FEBS Letters More from this journal
Volume:
592
Issue:
17
Pages:
2973-2986
Publication date:
2018-09-10
Acceptance date:
2018-07-12
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Pmid:
30025156

Language:
English
Keywords:
Pubs id:
pubs:891393
UUID:
uuid:ca0b3ab2-55f7-4dab-8602-6aca8c74f8ad
Local pid:
pubs:891393
Source identifiers:
891393
Deposit date:
2019-01-15

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