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Noncanonical functions of microRNA pathway enzymes – Drosha, DGCR8, Dicer and Ago proteins

Abstract:

MicroRNAs (miRNAs) are small regulatory noncoding RNAs that are generated in the canonical RNA interference (RNAi) pathway. Drosha, DiGeorge syndrome critical region 8 (DGCR8) and Dicer are key players in miRNA biogenesis. Argonaute (Ago) proteins bind to miRNAs and are guided by them to find messenger RNA targets and carry out post‐transcriptional silencing of protein‐coding genes. Recently, emerging evidence suggests that RNAi factors have a range of noncanonical functions that are beyond m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/1873-3468.13196

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-9940-1175
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
Senior Research Fellowship BVR01170
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/M011224/1
More from this funder
Name:
Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Publisher:
Wiley
Journal:
FEBS Letters More from this journal
Volume:
592
Issue:
17
Pages:
2973-2986
Publication date:
2018-09-10
Acceptance date:
2018-07-12
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Pmid:
30025156
Language:
English
Keywords:
Pubs id:
pubs:891393
UUID:
uuid:ca0b3ab2-55f7-4dab-8602-6aca8c74f8ad
Local pid:
pubs:891393
Source identifiers:
891393
Deposit date:
2019-01-15

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