Journal article
Noncanonical functions of microRNA pathway enzymes – Drosha, DGCR8, Dicer and Ago proteins
- Abstract:
-
MicroRNAs (miRNAs) are small regulatory noncoding RNAs that are generated in the canonical RNA interference (RNAi) pathway. Drosha, DiGeorge syndrome critical region 8 (DGCR8) and Dicer are key players in miRNA biogenesis. Argonaute (Ago) proteins bind to miRNAs and are guided by them to find messenger RNA targets and carry out post‐transcriptional silencing of protein‐coding genes. Recently, emerging evidence suggests that RNAi factors have a range of noncanonical functions that are beyond m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Oxford Interdisciplinary Bioscience Doctoral Training Partnership
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- FEBS Letters Journal website
- Volume:
- 592
- Issue:
- 17
- Pages:
- 2973-2986
- Publication date:
- 2018-09-10
- Acceptance date:
- 2018-07-12
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
- Pmid:
-
30025156
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:891393
- UUID:
-
uuid:ca0b3ab2-55f7-4dab-8602-6aca8c74f8ad
- Local pid:
- pubs:891393
- Source identifiers:
-
891393
- Deposit date:
- 2019-01-15
Terms of use
- Copyright holder:
- Pong and Gullerova
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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