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Emergence and clonal spread of colistin resistance due to multiple mutational mechanisms in carbapenemase-producing Klebsiella pneumoniae in London

Abstract:

Carbapenemase-producing Enterobacteriaceae (CPE) are emerging worldwide, limiting therapeutic options. Mutational and plasmid-mediated mechanisms of colistin resistance have both been reported. The emergence and clonal spread of colistin resistance was analysed in 40 epidemiologically-related NDM-1 carbapenemase producing Klebsiella pneumoniae isolates identified during an outbreak in a group of London hospitals. Isolates from July 2014 to October 2015 were tested for colistin susceptibility ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-12637-4

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National Institute for Health Research More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
12711
Publication date:
2017-10-05
Acceptance date:
2017-09-13
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:860179
URN:
uri:ca015e5c-b289-40cb-9408-bddf83c03579
UUID:
uuid:ca015e5c-b289-40cb-9408-bddf83c03579
Local pid:
pubs:860179
Language:
English
Keywords:

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