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Journal article

Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms

Abstract:

Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inher...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/tp.2016.294

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Goriely, A
Grant:
102731
More from this funder
Name:
Simons Foundation Autism Research Initiative
Funding agency for:
Basson, M
Grant:
344763
More from this funder
Name:
Medical Research Council
Funding agency for:
Janecka, M
Basson, M
Fernandes, C
Grant:
MR/J500380/1
344763
MR/K022377/1
Publisher:
Nature Publishing Group
Journal:
Translational Psychiatry More from this journal
Volume:
7
Issue:
e1019
Pages:
1-9
Publication date:
2017-01-31
Acceptance date:
2016-12-15
DOI:
ISSN:
2158-3188
Language:
English
Keywords:
Pubs id:
pubs:679618
UUID:
uuid:c9faeaf1-1fe1-4573-982a-d7813cfa15f6
Local pid:
pubs:679618
Source identifiers:
679618
Deposit date:
2017-06-12

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