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TFH-derived dopamine accelerates productive synapses in germinal centres

Abstract:

Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature23013

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
European Research Council
Funding agency for:
Dustin, M
Grant:
RGP0033/2015
More from this funder
Name:
D.S. Human Frontier Science Program
Funding agency for:
Dustin, M
Grant:
RGP0033/2015
More from this funder
Name:
Wellcome Trust
Funding agency for:
Valvo, S
Dustin, M
Grant:
RGP0033/2015
Publisher:
Springer Nature
Journal:
Nature More from this journal
Volume:
547
Issue:
7663
Pages:
318–323
Publication date:
2017-07-12
Acceptance date:
2017-06-06
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Pubs id:
pubs:708069
UUID:
uuid:c9fadef7-e488-4470-91f6-3b30ac17ac71
Local pid:
pubs:708069
Source identifiers:
708069
Deposit date:
2017-07-22

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