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Intrinsic protein disorder reduces small-scale gene duplicability

Abstract:

Whereas the rate of gene duplication is relatively high, only certain duplications survive the filter of natural selection and can contribute to genome evolution. However, the reasons why certain genes can be retained after duplication whereas others cannot remain largely unknown. Many proteins contain intrinsically disordered regions (IDRs), whose structures fluctuate between alternative conformational states. Due to their high flexibility, IDRs often enable protein–protein interactions and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/dnares/dsx015

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Name:
University of Nevada, Reno
Grant:
awarded to DAP
Publisher:
Oxford University Press
Journal:
DNA Research More from this journal
Volume:
24
Issue:
4
Pages:
435-444
Publication date:
2017-04-19
Acceptance date:
2017-03-28
DOI:
EISSN:
1756-1663
ISSN:
1340-2838
Pmid:
28430886
Language:
English
Keywords:
Pubs id:
pubs:836291
UUID:
uuid:c9fa809c-411e-425f-95ec-4e246dcc2d3d
Local pid:
pubs:836291
Source identifiers:
836291
Deposit date:
2018-04-17

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