Use of nonsteroidal anti-inflammatory drugs and risk of fractures.

Journal article

In animal models, prostaglandin synthesis has been found to mediate bone metabolism. Nonsteroidal anti-inflammatory drugs (NSAIDs), given their inhibitory effects of prostaglandin synthesis, may play a role in the prevention of osteoporosis. The primary objective of this study is to describe and quantify the fracture risks of patients exposed to NSAIDs in a representative general medical practice setting. A retrospective cohort study was conducted in a general medical practice setting in the ...

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Authors: van Staa, T; Leufkens, H; Cooper, C

• Publication status: Published
• Journal: Bone
• Volume: 27
• Issue: 4
• Pages: 563-568
• Publication date: 2000-10-01
• DOI: 10.1016/s8756-3282(00)00361-6
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Fractures, Bone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Middle Aged; Incidence; Cohort Studies; Humans