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Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

Abstract:

Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. Methods Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250, 500 and 1000 mg) after an overnight fast with a washout period of at least 6 weeks between doses. Patient data (n = 188) were obtained from randomised controlled trials conducted on the Thai-Burmese border in the early 1990...

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Journal:
Journal of Pharmacy and Pharmacology
Volume:
64
Issue:
11
Pages:
1603-1613
Publication date:
2012-11-05
DOI:
EISSN:
2042-7158
ISSN:
0022-3573
URN:
uuid:c9ee656b-eced-4281-a629-a1cfc0e406f9
Source identifiers:
356603
Local pid:
pubs:356603

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