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Journal article : Review

RAD51: beyond the break

Abstract:
As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.semcdb.2020.08.010

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0902-2364
Publisher:
Elsevier
Journal:
Seminars in Cell and Developmental Biology More from this journal
Volume:
113
Pages:
38-46
Publication date:
2020-09-13
Acceptance date:
2020-08-28
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
Pmid:
32938550
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1134739
Local pid:
pubs:1134739
Deposit date:
2021-12-09

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