Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses.

Journal article

The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the converse may also be true: more slowly replicating viruses may evoke weaker cellular immune responses and therefore enhance their likelihood of persistence. Using the model of lymphocytic choriomeningitis virus (LCMV) infection in mice, we provide evidence that slowly replicating strains induce weaker ...

Expand abstract

Authors: Bocharov, G; Ludewig, B; Bertoletti, A; Klenerman, P; Junt, T

• Publication status: Published
• Journal: Journal of virology
• Volume: 78
• Issue: 5
• Pages: 2247-2254
• Publication date: 2004-03-01
• DOI: 10.1128/jvi.78.5.2247-2254.2004
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Acute Disease; Lymphocytic choriomeningitis virus; Virus Replication; Chronic Disease; Hepatitis B virus; Models, Immunological; T-Lymphocytes, Cytotoxic; Kinetics; Mice, Inbred C57BL; Mice; Animals