ATM and Chk2 kinase target the p53 cofactor Strap.

Journal article

The p53 cofactor Strap (stress responsive activator of p300) is directly targeted by the DNA damage signalling pathway where phosphorylation by ATM (ataxia telangiectasia mutated) kinase facilitates nuclear accumulation. Here, we show that Strap regulation reflects the coordinated interplay between different DNA damage-activated protein kinases, ATM and Chk2 (Checkpoint kinase 2), where phosphorylation by each kinase provides a distinct functional consequence on the activity of Strap. ATM pho...

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Authors: Adams, C; Graham, A; Jansson, M; Coutts, A; Edelmann, M

• Publication status: Published
• Journal: EMBO reports
• Volume: 9
• Issue: 12
• Pages: 1222-1229
• Publication date: 2008-12-01
• DOI: 10.1038/embor.2008.186
• EISSN: 1469-3178
• ISSN: 1469-221X
• Language: English
• Keywords: Phosphorylation; Tumor Suppressor Protein p53; Amino Acid Sequence; Active Transport, Cell Nucleus; Cell Nucleus; Protein-Serine-Threonine Kinases; Protein Stability; Checkpoint Kinase 2; Cell Cycle Proteins; Cell Line; Molecular Sequence Data; DNA-Binding Proteins; Tumor Suppressor Proteins; Humans; Ataxia Telangiectasia Mutated Proteins; Neoplasm Proteins