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Superoxide production by NAD(P)H oxidase in human blood vessels: Functional interaction with nitric oxide

Abstract:

Increased superoxide (SO) production in animal models of vascular disease contributes to reduced nitric oxide (NO) activity, endothelial dysfunction and oxidative stress. However, the importance of SO production in human atherosclerosis is poorly characterised. We aimed to determine the sources of SO in human blood vessels, and study NO-SO interactions. Methods: We studied basal and NADH-stimulated SO production using lucigenin-enhanced chemiluminescence); NO-dependent vasorclaxations (as a b...

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Journal:
Heart More from this journal
Volume:
83
Issue:
SUPPL. 1
Publication date:
2000-05-01
ISSN:
1355-6037
Language:
English
Pubs id:
pubs:106025
UUID:
uuid:c9d76f4d-5e4f-4c10-833d-280cee2e240e
Local pid:
pubs:106025
Source identifiers:
106025
Deposit date:
2012-12-19

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