- Abstract:
-
Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual expression program within TEC populations and single cells are unknown. Using deep transcriptome sequencing of carefully identified mouse TEC subpopulations, we discovered a program of PGE that is common between medullary (m) and cortical TEC...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1101/gr.171645.113
-
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- Publisher:
- Cold Spring Harbor Laboratory Press
- Journal:
- Genome research
- Volume:
- 24
- Issue:
- 12
- Pages:
- 1918-1931
- Publication date:
- 2014-12-05
- DOI:
- EISSN:
-
1549-5469
- ISSN:
-
1088-9051
- URN:
-
uuid:c9d6a1ca-058c-45d4-9f7c-536326bee125
- Source identifiers:
-
484656
- Local pid:
- pubs:484656
- Language:
- English
- Copyright date:
- 2014
Journal article
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.
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