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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

Abstract:

Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual expression program within TEC populations and single cells are unknown. Using deep transcriptome sequencing of carefully identified mouse TEC subpopulations, we discovered a program of PGE that is common between medullary (m) and cortical TEC...

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Publication status:
Published

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Publisher copy:
10.1101/gr.171645.113

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Shikama-Dorn, N More by this author
Zhanybekova, S More by this author
Nusspaumer, G More by this author
Macaulay, IC More by this author
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Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genome research
Volume:
24
Issue:
12
Pages:
1918-1931
Publication date:
2014-12-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:c9d6a1ca-058c-45d4-9f7c-536326bee125
Source identifiers:
484656
Local pid:
pubs:484656
Language:
English

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