Journal article
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
- Abstract:
-
Cases of SARS-CoV-2 infection in Manaus, Brazil, resurged in late 2020, despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1, acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor. Molecular clock analysis shows that P.1 emergence oc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 372
- Issue:
- 6544
- Pages:
- 815-821
- Publication date:
- 2021-04-14
- Acceptance date:
- 2021-04-11
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Pmid:
-
33853970
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1171716
- Local pid:
- pubs:1171716
- Deposit date:
- 2021-04-26
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2021
- Rights statement:
- © 2021, American Association for the Advancement of Science
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