Journal article icon

Journal article

Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.

Abstract:

For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes may be less painful than larger tubes, but efficacy in pleurodesis has not been proven.To assess the effect of chest tube size and analgesia (NSAIDs vs opiates) on pain and clinical efficacy related to pleurodesis in patients with malignant pleural effusion.A 2×2 factorial phase 3 randomized clinical trial among 320 patients r...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1001/jama.2015.16840

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Rahman, N
Grant:
G0600475
More from this funder
Name:
National Institute for Health Research Oxford Biomedical Research Centre Programme
Funding agency for:
Rahman, N
Publisher:
American Medical Association
Journal:
Journal of the American Medical Association More from this journal
Volume:
314
Issue:
24
Pages:
2641-2653
Publication date:
2015-12-22
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
Language:
English
Pubs id:
pubs:585951
UUID:
uuid:c9c52e68-5fd9-438a-bae7-5cdbf50b453d
Local pid:
pubs:585951
Source identifiers:
585951
Deposit date:
2016-02-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP