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Journal article

Use of lipoteichoic acid-T for pleurodesis in malignant pleural effusion: a phase I toxicity and dose-escalation study.

Abstract:

BACKGROUND: Bacterial infection of the pleural space often causes adherence of the pleural membranes by fibrous tissue, probably mediated by inflammation initiated by bacterial cell-wall motifs, including lipoteichoic acid-T (LTA-T). We postulated that therapeutically administered LTA-T might produce a similar effect, achieving control of malignant pleural effusion (pleurodesis). METHODS: Patients with histocytologically proven symptomatic malignant pleural effusions were included in this pha...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
The Lancet. Oncology
Volume:
9
Issue:
10
Pages:
946-952
Publication date:
2008-10-05
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
URN:
uuid:c9c4f6a1-b79e-41a7-a1cb-6b6388edd02c
Source identifiers:
14201
Local pid:
pubs:14201

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