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Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2.

Abstract:

Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and plays a central role in angiogenesis and vasculogenesis. Therefore, VEGF and its receptors VEGFR-1 and VEGFR-2 are prime targets for anti-angiogenic intervention which is thought to be one of the most promising approaches in cancer therapy. Recently, we have discovered a VEGFR-2-derived peptide ((247)RTELNVGIDFNWEYP(261)) representing a potential binding site to VEGF. Using the spot synthesis technique, sy...

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Publication status:
Published

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Publisher copy:
10.1267/THRO03030501

Authors


Piossek, C More by this author
Thierauch, KH More by this author
Schneider-Mergener, J More by this author
Volkmer-Engert, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Thrombosis and haemostasis
Volume:
90
Issue:
3
Pages:
501-510
Publication date:
2003-09-05
DOI:
ISSN:
0340-6245
URN:
uuid:c9c4dd23-9ac7-4af4-bbaa-b22ff43f4b20
Source identifiers:
469739
Local pid:
pubs:469739

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