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Oscillating magnet array−based nanomagnetic gene transfection: A valuable tool for molecular neurobiology studies

Abstract:

To develop treatments for neurodegenerative disorders, it is critical to understand the biology and function of neurons in both normal and diseased states. Molecular studies of neurons involve the delivery of small biomolecules into cultured neurons via transfection to study genetic variants. However, as cultured primary neurons are sensitive to temperature change, stress, and shifts in pH, these factors make biomolecule delivery difficult, particularly non-viral delivery. Herein we used osci...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/nano7020028

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
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nanoTherics limited More from this funder
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Grant:
PITN-GA-2012-290248
Publisher:
MDPI Publisher's website
Journal:
Nanomaterials Journal website
Volume:
7
Issue:
2
Pages:
28-28
Publication date:
2017-01-05
Acceptance date:
2017-01-23
DOI:
ISSN:
2079-4991
Pubs id:
pubs:681785
URN:
uri:c9bf629b-9812-431c-a4d2-4d11c063e873
UUID:
uuid:c9bf629b-9812-431c-a4d2-4d11c063e873
Local pid:
pubs:681785

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