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The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.

Abstract:

Macrophage Scavenger Receptor A (SR-A) is a major non-opsonic receptor for Neisseria meningitidis on mononuclear phagocytes in vitro, and the surface proteins NMB0278, NMB0667, and NMB1220 have been identified as ligands for SR-A. In this study we ascertain the in vivo role of SR-A in the recognition of N. meningitidis MC58 (serogroup B) in a murine model of meningococcal septicaemia. We infected wild-type and SR-A(-/-) animals intraperitoneally with N. meningitidis MC58 and monitored their h...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000297

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Institution:
University of Oxford
Role:
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Moxon, E
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
5
Issue:
2
Pages:
e1000297
Publication date:
2009-02-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
5918

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