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Journal article

RIGorous detection: exposing virus through RNA sensing.

Abstract:

Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I-like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-...

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Publication status:
Published

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Publisher copy:
10.1126/science.1185068

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Journal:
Science (New York, N.Y.)
Volume:
327
Issue:
5963
Pages:
284-286
Publication date:
2010-01-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:c9bdb2dc-46f7-4fc3-b991-931ea7ca65cc
Source identifiers:
327350
Local pid:
pubs:327350

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