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A novel bioassay for B-cell activating factor (BAFF) based on expression of a BAFF-receptor ectodomain-tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 endodomain fusion receptor in human rhabdomyosarcoma cells.

Abstract:

B-cell activating factor (BAFF) is a type II transmembrane glycoprotein belonging to the tumour necrosis factor ligand superfamily. Active soluble forms of BAFF are generated either by cleavage of the extracellular domain or by recombinant DNA technology. The current bioassay for measuring the activity of soluble BAFF involves stimulation of the proliferation of mouse splenic B-cells in the presence of goat anti-mouse IgMmicro chain which is rather cumbersome and lengthy and yields variable r...

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Publisher copy:
10.1016/j.jim.2008.05.013

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Journal:
Journal of immunological methods
Volume:
337
Issue:
1
Pages:
63-70
Publication date:
2008-08-01
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
Source identifiers:
479531

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