Journal article icon

Journal article

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas

Abstract:

Platinum drug-resistance in ovarian cancers is a major factor contributing to chemotherapeutic resistance of recurrent disease. Members of the Bcl-2 family such as the anti-apoptotic protein Bcl-XL have been shown to play a role in this resistance. Consequently, concurrent inhibition of Bcl-XL in combination with standard chemotherapy may improve treatment outcomes for ovarian cancer patients. Here, we develop a mathematical model to investigate the potential of combination therapy with ABT-7...

Expand abstract

Actions


Access Document


Files:
Publication date:
2012-01-01
UUID:
uuid:c9b93f1f-b847-4c46-8883-b16d7305de3a
Local pid:
oai:eprints.maths.ox.ac.uk:1666
Deposit date:
2013-02-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP