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The murine p75 TNF receptor promoter region: DNA sequence and characterization of a cis-acting silencer.

Abstract:

The promoter region of the murine p75 TNF receptor (TNF-R) was isolated from a mouse genomic DNA cosmid library. The promoter region is devoid of TATA box and has the characteristics of a house keeping gene since it contains multiple SP1 binding sites. Its mRNA has different initiation sites in different lymphoid cell lines. This promoter confers transcriptional activity to heterologous reporter genes. Deletion analysis showed that there is a silencer element located upstream from position -8...

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Publication status:
Published

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Authors


Kissonerghis, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Chernajovsky, Y More by this author
Journal:
Molecular immunology
Volume:
36
Issue:
2
Pages:
125-134
Publication date:
1999-02-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:c9b22c58-4fc1-44bc-a35a-3c3368dc3621
Source identifiers:
481581
Local pid:
pubs:481581

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