- Abstract:
-
Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (KATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50]=2.5 mmol/l) reduction of glucagon release. Maximum inhibition (approximately 50%) was attained at glucose concentrations >5 mmol/l. The sulfonylureas to...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2337/diabetes.53.suppl_3.S181
-
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- Volume:
- 53 Suppl 3
- Issue:
- Supplement 3
- Pages:
- S181-S189
- Publication date:
- 2004-12-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- URN:
-
uuid:c9a8080a-26c5-49c6-8c66-5e8d95673b0d
- Source identifiers:
-
20163
- Local pid:
- pubs:20163
- Copyright date:
- 2004
Conference
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
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