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ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

Abstract:

Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (KATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50]=2.5 mmol/l) reduction of glucagon release. Maximum inhibition (approximately 50%) was attained at glucose concentrations >5 mmol/l. The sulfonylureas to...

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Publication status:
Published

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Volume:
53 Suppl 3
Issue:
Supplement 3
Pages:
S181-S189
Publication date:
2004-12-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:c9a8080a-26c5-49c6-8c66-5e8d95673b0d
Source identifiers:
20163
Local pid:
pubs:20163

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