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The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

Abstract:

The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinico-pathological phenotypes in human transmissible spongiform encephalopathies. The molecular mechanisms by which the effect of this polymorphism are mediated remain unclear. It has been shown that the folding, dynamics and stability of the physiological, alpha-helix-rich form of recombinant PrP are not affected by codon 129 polymorphism. Consistent with this, we have recently shown that the ki...

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Publication status:
Published

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Authors


Baskakov, I More by this author
Disterer, P More by this author
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Journal:
FEBS letters
Volume:
579
Issue:
12
Pages:
2589-2596
Publication date:
2005-05-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:c9a747dd-8f8f-415f-9774-9bdd66aa477c
Source identifiers:
6150
Local pid:
pubs:6150

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