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Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth hormone pulsatility in young adults with type I diabetes mellitus.

Abstract:

To investigate whether recombinant human insulin-like growth factor-I (rhIGF-I) has direct effects on the insulin requirement to maintain euglycemia independent of the growth hormone (GH) level, nine subjects with insulin-dependent diabetes mellitus ([IDDM] seven females; median (range) age, duration of diabetes, and hemoglobin A1C [HbA1C], 16.9 (12.5 to 21.9) years, 11.8 (4.6 to 16.8) years, and 9.8% (7.9% to 14.1%), respectively) underwent two euglycemic studies (6:00 PM to 8:00 AM) after d...

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Publication status:
Published

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Journal:
Metabolism: clinical and experimental
Volume:
47
Issue:
1
Pages:
31-38
Publication date:
1998-01-01
DOI:
EISSN:
1532-8600
ISSN:
0026-0495
Source identifiers:
410494
Language:
English
Keywords:
Pubs id:
pubs:410494
UUID:
uuid:c9a2a13a-0315-4675-9a99-d28a71c438ec
Local pid:
pubs:410494
Deposit date:
2013-11-17

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