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A computational comparison of the multiple-breath washout and forced oscillation technique as markers of bronchoconstriction

Abstract:

Many types of lung disease lead to constriction of airways within the conducting zone, causing increases in airway resistance and ventilation heterogeneity (VH). The multiple-breath washout (MBW) and forced oscillation technique (FOT) are two clinical measures of small airway bronchoconstriction. Within this study computational modelling of the MBW and FOT was applied to the analysis of thousands of bronchoconstriction scenarios in the conducting zone of the lungs. The simulations show that M...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.resp.2017.02.016

Authors


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Institution:
University of Oxford
Oxford college:
New College
Role:
Author
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Institution:
University of Oxford
Oxford college:
Green Templeton College
Role:
Author
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Name:
Rhodes Trust
Funding agency for:
Foy, B
Grant:
RhodesScholarship,Queensl
, 2015
Publisher:
Elsevier
Journal:
Respiratory Physiology & Neurobiology More from this journal
Volume:
240
Pages:
61–69
Publication date:
2017-03-12
Acceptance date:
2017-02-23
DOI:
ISSN:
1569-9048
Keywords:
Pubs id:
pubs:681477
UUID:
uuid:c99d2d0f-b59c-4ad8-a97b-619f9c65c805
Local pid:
pubs:681477
Source identifiers:
681477
Deposit date:
2017-02-24

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