Journal article
Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
- Abstract:
-
The protein tyrosine kinase ZAP-70, which mediates T-cell antigen receptor (TCR) signalling, contains three distinct functional modules, two tandemly arranged SH2 domains, a kinase domain and a linker region (interdomain B) that connects them. ZAP-70 enzymatic activation is strictly dependent on the binding, via its SH2 domains, to the triggered TCR and on tyrosine phosphorylation. Here we utilized recombinant ZAP-70 and carried out a mutational analysis to understand the structural requireme...
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- Publication status:
- Published
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- Publisher copy:
- 10.1046/j.1432-1327.1999.00973.x
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Authors
Bibliographic Details
- Journal:
- European journal of biochemistry / FEBS
- Volume:
- 266
- Issue:
- 3
- Pages:
- 1166-1173
- Publication date:
- 1999-12-01
- DOI:
- EISSN:
-
1432-1033
- ISSN:
-
0014-2956
- Source identifiers:
-
19035
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:19035
- UUID:
-
uuid:c9992a13-7406-403a-809e-5d120b0b7a04
- Local pid:
- pubs:19035
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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