Journal article icon

Journal article

Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.

Abstract:

The protein tyrosine kinase ZAP-70, which mediates T-cell antigen receptor (TCR) signalling, contains three distinct functional modules, two tandemly arranged SH2 domains, a kinase domain and a linker region (interdomain B) that connects them. ZAP-70 enzymatic activation is strictly dependent on the binding, via its SH2 domains, to the triggered TCR and on tyrosine phosphorylation. Here we utilized recombinant ZAP-70 and carried out a mutational analysis to understand the structural requireme...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
European journal of biochemistry / FEBS
Volume:
266
Issue:
3
Pages:
1166-1173
Publication date:
1999-12-01
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
Source identifiers:
19035

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP