Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects.

Journal article

BACKGROUND AND METHODS: Autism is a severe neurodevelopmental disorder, which has a complex genetic predisposition. The ratio of males to females affected by autism is approximately 4:1, suggesting that sex specific factors are involved in its development. We reported previously the results of a genomewide screen for autism susceptibility loci in 83 affected sibling pairs (ASP), and follow up analysis in 152 ASP. Here, we report analysis of an expanded sample of 219 ASP, using sex and parent...

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Authors: Lamb, J; Barnby, G; Bonora, E; Sykes, N; Bacchelli, E

• Publication status: Published
• Journal: Journal of medical genetics
• Volume: 42
• Issue: 2
• Pages: 132-137
• Publication date: 2005-02-01
• DOI: 10.1136/jmg.2004.025668
• EISSN: 1468-6244
• ISSN: 0022-2593
• Language: English
• Keywords: Sex Factors; Male; Siblings; Genomic Imprinting; Humans; Female; Parents; Genetic Predisposition to Disease; International Molecular Genetic Study of Autism Consortium (IMGSAC); Autistic Disorder; Genetic Linkage