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Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence.

Abstract:

In acute infectious mononucleosis (AIM), very large clones of Ag-specific CD8+ effector T cells are generated. Many clones persist as memory cells, although the clone size is greatly reduced. It would be expected that the large number of cell divisions occurring during clonal expansion would lead to shortening of telomeres, predisposing to replicative senescence. Instead, we show that clonally expanded CD8+ T cells in AIM have paradoxical preservation of telomere length in association with ma...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
162
Issue:
8
Pages:
4521-4526
Publication date:
1999-04-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c992fe93-476d-40da-b8d6-11fd6623ed9a
Source identifiers:
31465
Local pid:
pubs:31465

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