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Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.

Abstract:

BACKGROUND: We examined the strategy of T-cell depletion of HLA-identical sibling grafts for the prevention of GvHD, as well as disease control and overall survival. PATIENTS AND METHODS: The myeloablative conditioning was radiation based. The source of stem cells was BM in 62, and cytokine-mobilized PBPC in 68 patients. GvHD prophylaxis was by ex vivo incubation of the stem-cell concentrates with Campath-1G (anti-CD52; n=76) or Campath-1H (n=54). RESULTS: Patients receiving PBPC grafts were...

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Publication status:
Published

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Publisher copy:
10.1080/14653240310004520

Authors


Novitzky, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Cytotherapy
Volume:
6
Issue:
2
Pages:
172-181
Publication date:
2004
DOI:
EISSN:
1477-2566
ISSN:
1465-3249
URN:
uuid:c98fbd17-adbd-4041-83d4-1e2afd3800d5
Source identifiers:
15218
Local pid:
pubs:15218

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