Expression of MHC class I-related Chain B (MICB) molecules on renal transplant biopsies.

Journal article

BACKGROUND: MICA and MICB (MHC class I-related chain A and B) are polymorphic genes that encode molecules related to MHC class I and are expressed on epithelial cells in response to stress. Incompatible donor MIC antigens can stimulate antibody production in transplant recipients. This study was designed to determine MICB expression in kidney pretransplant and any subsequent changes in expression following transplantation and to correlate changes with inflammatory markers and clinical events...

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Authors: Quiroga, I; Salio, M; Koo, D; Cerundolo, L; Shepherd, D

• Publication status: Published
• Journal: Transplantation
• Volume: 81
• Issue: 8
• Pages: 1196-1203
• Publication date: 2006-04-01
• DOI: 10.1097/01.tp.0000205788.05322.42
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Humans; Immunohistochemistry; Middle Aged; Adult; Colon; Histocompatibility Antigens Class I; Leukocytes; Histocompatibility Antigens Class II; Aged; Kidney Transplantation; Kidney; Female; Biopsy; Male; Antibody Specificity