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Structural characterisation of the human alpha-lactalbumin molten globule at high temperature.

Abstract:

Molten globules are partially folded forms of proteins thought to be general intermediates in protein folding. The 15N-1H HSQC NMR spectrum of the human alpha-lactalbumin (alpha-LA) molten globule at pH 2 and 20 degrees C is characterised by broad lines which make direct study by NMR methods difficult; this broadening arises from conformational fluctuations throughout the protein on a millisecond to microsecond timescale. Here, we find that an increase in temperature to 50 degrees C leads to ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Journal of molecular biology
Volume:
330
Issue:
5
Pages:
1177-1188
Publication date:
2003-07-01
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Source identifiers:
100355
Language:
English
Keywords:
Pubs id:
pubs:100355
UUID:
uuid:c98c2bae-0f18-40a9-83fa-6e4e9090c563
Local pid:
pubs:100355
Deposit date:
2012-12-19

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