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Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.

Abstract:

Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for "crosspresentation" via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed "crosstolerance." However, up to now it has been unknown whether "crosstolerance" can also cont...

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Journal:
Immunity More from this journal
Volume:
28
Issue:
4
Pages:
521-532
Publication date:
2008-04-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Language:
English
Keywords:
Pubs id:
pubs:422416
UUID:
uuid:c980c2b4-b474-4b42-b370-7861c77c0a2f
Local pid:
pubs:422416
Source identifiers:
422416
Deposit date:
2014-06-17

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