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A large-scale assessment of temporal trends in meta-analyses using systematic review reports from the Cochrane Library

Abstract:

Introduction: Previous studies suggest many systematic reviews contain meta-analyses that display temporal trends, such as the first study’s result being more extreme than later studies’, or a drift in the pooled estimate. We assessed the extent and characteristics of temporal trends using all Cochrane intervention reports published 2008-2012.

Methods: We selected the largest meta-analysis within each report and analysed trends using methods including a Z-test (first versus subseq...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/jrsm.1238

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
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Grant:
Research Methods Fellowship (GS) and Internship (LS) (NIHR-RMFI-2015-05-015)
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Research Synthesis Methods Journal website
Volume:
8
Issue:
4
Pages:
404–415
Publication date:
2017-05-11
Acceptance date:
2017-02-17
DOI:
EISSN:
1759-2887
ISSN:
1759-2879
Pubs id:
pubs:680723
URN:
uri:c97cd33b-dba9-4ce5-b208-8de55aca3fce
UUID:
uuid:c97cd33b-dba9-4ce5-b208-8de55aca3fce
Local pid:
pubs:680723

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