- Abstract:
-
BACKGROUND: Reproductive factors have been shown by epidemiology studies to alter colorectal cancer risk in women. Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine. The Min mouse provides a good model of FAP, and we recently reported a significant increase in intestinal tumour multiplicity in a recombinant line of mice following pregnancy. AIM: We considered whether reproductio...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1136/jmg.2007.049965
-
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- Journal:
- Journal of medical genetics
- Volume:
- 44
- Issue:
- 8
- Pages:
- 541-544
- Publication date:
- 2007-08-05
- DOI:
- EISSN:
-
1468-6244
- ISSN:
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0022-2593
- URN:
-
uuid:c97c0d58-90bb-4205-9900-5187a1b15e04
- Source identifiers:
-
72060
- Local pid:
- pubs:72060
- Copyright date:
- 2007
Journal article
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
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