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Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

Abstract:

BACKGROUND: Reproductive factors have been shown by epidemiology studies to alter colorectal cancer risk in women. Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine. The Min mouse provides a good model of FAP, and we recently reported a significant increase in intestinal tumour multiplicity in a recombinant line of mice following pregnancy. AIM: We considered whether reproductio...

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Publication status:
Published

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Publisher copy:
10.1136/jmg.2007.049965

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Journal:
Journal of medical genetics
Volume:
44
Issue:
8
Pages:
541-544
Publication date:
2007-08-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:c97c0d58-90bb-4205-9900-5187a1b15e04
Source identifiers:
72060
Local pid:
pubs:72060

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