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Journal article

10-Helical conformations in oxetane beta-amino acid hexamers

Abstract:
The first structural investigations were undertaken on a β-hexapeptide 7 in which the peptide backbone is constrained by cis-substituted oxetane rings. Detailed NMR studies in CDCl3 and C6D6 together with molecular mechanics conformational analysis identify a well-defined left-handed helical structure stabilised by 10-membered hydrogen-bonded rings. Comparison with two related hexapeptides 8 and 9 suggests a similar structural preference for these systems. © 2001 Elsevier Science Ltd.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Goodman, JM More by this author
Barker, SF More by this author
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Journal:
TETRAHEDRON LETTERS
Volume:
42
Issue:
25
Pages:
4251-4255
Publication date:
2001-06-18
DOI:
ISSN:
0040-4039
URN:
uuid:c97ba0b8-9daf-4a20-bc40-332c2e3184fd
Source identifiers:
37849
Local pid:
pubs:37849
Language:
English

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