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Defective assembly of class I major histocompatibility complex molecules in an embryonic cell line.

Abstract:

Developmentally regulated expression of the products of the major histocompatibility complex (MHC) is thought to play a key role in maternal tolerance of the fetal allograft. Here we analyze a cell line (EE2H3), derived from early post-implantation-stage mouse embryos, that is defective for MHC class I assembly. To follow expression of a single well-defined class I product, we introduced the H-2Dd gene under control of the human beta-actin promoter. We found that the transfected EE2H3 cells e...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830210905

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
21
Issue:
9
Pages:
1997-2004
Publication date:
1991-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:c977797e-59e4-4851-84a6-bb6ca8377c12
Source identifiers:
6592
Local pid:
pubs:6592

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