Antenatal screening in Oxford for fetal neural tube defects.

Journal article

Between May 1975 and the end of 1977, 6443 antenatal patients were screened mainly between 16 and 22 weeks of pregnancy for neural tube defects (NTDs) at the John Radcliffe Hospital, Oxford, by maternal serum alpha-fetoprotein (AFP) measurement; a take-up of 72 per cent. Seventeen out of 18 (94 per cent) patients with open NTD pregnancies (9 out of 9 with anencephaly and 8 out of 9 with open spina bifida) had positive screening tests, and all except one were offered and accepted a termination...

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Authors: Wald, N; Cuckle, H; Boreham, J; Brett, R; Stirrat, G

• Publication status: Published
• Journal: British journal of obstetrics and gynaecology
• Volume: 86
• Issue: 2
• Pages: 91-100
• Publication date: 1979-02-01
• DOI: 10.1111/j.1471-0528.1979.tb10574.x
• EISSN: 1471-0528
• ISSN: 0306-5456
• Language: English
• Keywords: Mass Screening; Neural Tube Defects; Prenatal Diagnosis; alpha-Fetoproteins; Pregnancy; Humans; False Positive Reactions; England; Amniocentesis; Female; Costs and Cost Analysis; Ultrasonography